Tissue and organ formation relies on a hierarchy of processes that perform specific functions. These processes depend on tissue morphology, topology, as well as on physical and chemical characteristics. Physical and geometric tissue characteristics emerge from collective cellular behaviors and often involve qualitative changes in their collective states. These changes can be understood as collective transitions arising from cellular interactions and feedback.
Our aim
Our Aim is to reveal the physical principles that underlie the emergence of functional structures in living tissues. From a biological perspective, we will establish how tissue structure and function emerge from cell behaviors and their interactions. To achieve this result, concepts for collective transitions involving topology, energetics, mechanics, electricity and chemistry in active materials will be developed. A particular focus will be on how collective transitions govern the spatiotemporal organization of multicellular systems.
Topological Morphogenesis
RESEARCH TOPIC 1
Mechano-Electro-Chemical Self-Organization
RESEARCH TOPIC 2
Spatiotemporal Control of Tissue Material Transitions
RESEARCH TOPIC 3
Energy Flows and Metabolic Patterning in Morphogenesis
RESEARCH TOPIC 4
RA Leading Team
Catherina G. Becker
Otger Campàs
Anne Grapin-Botton
Rita Mateus
PoL Groups
Elias Barriga
Catherina G. Becker
Jan Brugués
Otger Campàs
Adele Doyle
Miki Ebisuya
Elisabeth Fischer-Friedrich
Stephan W. Grill
Anne Grapin-Botton
Benjamin Friedrich
Alf O. Honigmann
Meritxell Huch
Frank Jülicher
Christina Kurzthaler
Rita Mateus
Ivo F. Sbalzarini
Carsten Werner
Xingbo Yang
PoL Associates
Sebastian Aland
Michael Brand
Christian Dahmann
Carl Modes
Benjamin Schumann
Pavel Tomancak
Jesse Veenvliet
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Our work is driven by a sparkling collaborative atmosphere in Dresden between University and non-University research laboratories.